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Die Überwindung der Wirkstoffresistenz von Malariaparasiten gegen verfügbare Medikamente kann durch den Einsatz von Wirkstoffhybriden gelingen, wie S. B. Tsogoeva, L. Ackermann, J. Wang et al. in ihrem Forschungsartikel auf S. 13200 ff. berichten. Die Kombination zweier unterschiedlich wirkender Medikamente (z. B. Artemisinin und Chloroquin) in einer Hybridverbindung führt zur gleichzeitigen zellulären...
A substantial challenge worldwide is emergent drug resistance in malaria parasites against approved drugs, such as chloroquine (CQ). To address these unsolved CQ resistance issues, only rare examples of artemisinin (ART)‐based hybrids have been reported. Moreover, protein targets of such hybrids have not been identified yet, and the reason for the superior efficacy of these hybrids is still not known...
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