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Heat stress (HS) reaction is a stress response caused by adverse conditions. Currently, the incidence of reproductive malignancies particularly in males has been constantly increasing. This work investigated the effects of saponins derived from the stems and leaves of Panax ginseng (GSLS) on testicular injury induced by scrotal hyperthermia in mice. GSLS (150, 300 mg/kg) were administered intragastrically...
Acute liver injury (ALI) induced by acetaminophen (APAP) overdose is the most common cause of drug‐induced liver injury. Saponins from Platycodon grandiflorum (PGSs) ameliorate alcohol‐induced hepatotoxicity and enhance human lung carcinoma cell death via AMPK signaling pathway. However, whether PGS could protect from APAP‐induced ALI through AMPK activation and its downstream signals is still poorly...
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