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Purpose We report a more reliable method for determination of the herbicide diquat (DQ) in human biological samples using stable isotope dilution liquid chromatography–tandem mass spectrometry (LC–MS/MS). DQ-d8, a newly synthesized stable isotope was used as the internal standard (IS) for quantification of DQ instead of DQ-d4 typically used so far. The use of DQ-d8 could completely prevent errors...
Aripiprazole, a partial agonist of dopamine D2 receptors, is primarily metabolized to active dehydroaripiprazole and then converted to its urinary metabolites 1-(2,3-dichlorophenyl) piperazine (DCPP) and 3,4-dihydro-7-(3′carboxy) propoxy-2(1H) quinolinone (DCPQ). This study aimed to develop a simultaneous determination method for aripiprazole and its three metabolites in human plasma using isocratic...
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