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An ultraperformance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (UPLC/ESI–MS/MS) procedure was used to identify trace levels of metabolites after the administration of acarviostatin II03 or III03 to rats. Biosamples of the feces and urine of the treated rats as well as the intestinal sacs incubated with the drugs in vitro were pre-treated by cation-exchange...
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