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A 13 C-enriched phosphorylcholine polymer ( 13 C-PMPC) as a self-traceable MR (magnetic resonance) tag was conjugated with a fragment (scFv) of Herceptin, a clinical antibody against antigen Her2. When injected in model mice bearing Her2(+) (gastric) and Her2(−) (pancreatic) tumors, the antibody-tag conjugate 13 C-PMPC-scFv selectively accumulated in the Her2(+) tumor with...
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