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It is well-known that sphingosine-1-phosphate (S1P), the phospholipid content of HDL, binding to S1P receptors can raise COX-2 expression and PGI 2 release through p38MAPK/CREB pathway. In the present study we assess the action of SR-B1 initiated PI3K–Akt–eNOS signaling in the regulation of COX-2 expression and PGI 2 production in response to HDL. We found that apoA1 could increase...
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