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Phase-change ultrasound contrast agents (PCCAs), have shown promises for ultrasound-mediated diagnostics and therapeutics. High-frame-rate ultrasound imaging with microbubbles significantly improved temporal resolution and contrast compared to conventional contrast-enhanced ultrasound imaging, offering opportunities to observe and better understand PCCA behavior after vaporisation. In this study,...
The sub-micron perfluorocarbon-based phase change contrast agents (PCCAs) have shown great potential for imaging both microvasculature and tumour microenvironment. However the effect of geometrical confinement on the acoustic vaporisation has not been explored. We report the investigation of the difference in PCCA-produced contrast increase after activation with and without a microvessel confinement...
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