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The RNA‐binding protein, UPF1, is best known for its central role in the nonsense‐mediated RNA decay (NMD) pathway. Feng et al. now report a new function for UPF1—it is an E3 ubiquitin ligase that specifically promotes the decay of a key pro‐muscle transcription factor: MYOD. UPF1 achieves this through its RING‐like domain, which confers ubiquitin E3 ligase activity. Feng et al. provide evidence...
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