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Background
Thrombosis is a known consequence of intraportal islet transplantation, particularly for xenogeneic islets. To define the origins of thrombosis after islet xenotransplantation and relate it to early inflammation, we examined porcine islets transplanted into non‐human primates using a dual‐transplant model to directly compare islet characteristics.
Methods
α1,3‐Galactosyltransferase gene‐knockout...
Background
Membrane cofactor protein CD46 attenuates the complement cascade by facilitating cleavage of C3b and C4b. In solid organ xenotransplantation, organs expressing CD46 have been shown to resist hyperacute rejection. However, the incremental value of human CD46 expression for islet xenotransplantation remains poorly defined.
Methods
This study attempted to delineate the role of CD46 in early...
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