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BACKGROUND
Despite recent advances in allogeneic hematopoietic stem cell transplantation (AHSCT), the outcome of patients who have acute myeloid leukemia (AML) with a complex karyotype (CK) remains poor. The objective of this study was to identify prognostic factors associated with post‐transplantation survival in a large cohort of patients with CK AML.
METHODS
In total, data on 1342 consecutively...
BACKGROUNDThe optimal intensity of myeloablation delivered as part of a reduced‐intensity/toxicity conditioning (RIC/RTC) regimen to decrease the recurrence rate, without increasing nonrecurrence mortality (NRM), remains to be established.
METHODSThe current phase 2, prospective, multicenter trial aimed to assess the efficacy and safety of an RIC/RTC regimen based on busulfan at a dose of 130 mg/m...
BACKGROUNDThe objective of the current study was to investigate the role of postremission consolidation chemotherapy before reduced‐intensity conditioning (RIC) allogeneic stem cell transplantation (alloSCT) for patients with acute myeloid leukemia (AML) in first complete remission (CR1).
METHODSOf the 789 consecutive patients with AML in CR1 who underwent RIC alloSCT from a human leukocyte antigen‐matched...
Reduced‐intensity conditioning (RIC)‐alloSCT is increasingly used for acute myelogenous leukemia. Limited data are available for the comparison of peripheral blood stem cells with bone marrow for RIC‐alloSCT. We used the European Group for Blood and Marrow Transplantation (EBMT) ALWP data to compare the outcome of mobilized peripheral blood stem cells (PBSC) (n = 1430) vs. bone marrow (BM) (n = 107)...
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