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Cell cycle progression requires the E3 ubiquitin ligase anaphase-promoting complex (APC/C), which uses the substrate adaptors CDC20 and CDH1 to target proteins for proteasomal degradation. The APC CDH1 substrate cyclin A is critical for the G1/S transition and, paradoxically, accumulates even when APC CDH1 is active. We show that the deubiquitinase USP37 binds CDH1 and removes degradative...
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