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The cytotoxic activity of two Ru(II) complexes against A549, BEL-7402, HeLa, PC-12, SGC-7901 and SiHa cell lines was investigated by MTT method. Complexes 1 and 2 show moderate cytotoxicity toward BEL-7402 cells with an IC50 value of 53.9±3.4 and 39.3±2.1μM. The effects of the complexes inducing apoptosis, cellular uptake, reactive oxygen species and mitochondrial membrane potential in BEL-7402 cells...
A new Ru(II) complex, [Ru(ttbpy)2(NMIP)](ClO4)2 (ttbpy=4,4′-di-tert butyl-2,2′-bipyridine, NMIP=2′-(2″-nitro-3″,4″-methylenedioxyphenyl)imidazo[4′,5′-f][1,10]-phenanthroline), has been synthesized and characterized by elemental analysis, ESI-MS and 1H NMR spectroscopy. The complex induces a decrease in fluorescent intensity upon binding to protein bovine serum albumin (BSA). The cytotoxic activity...
A new Ru(II) complex [Ru(dmp)2(NMIP)](ClO4)2 (dmp = 2,9-dimethyl-1,10-phenanthroline, NMIP = 2’-(2″-nitro-3″,4″-methylenedioxyphenyl)imidazo[4′,5′-f][1,10]-phenanthroline) was synthesized and characterized by elemental analysis, ESI–MS and 1H NMR. The cytotoxic activity of the complex against MG-63, U2OS, HOS, and MC3T3-e1 cell lines was investigated by MTT method. The complex shows moderate cytotoxicity...
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