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The binding of pazufloxacin mesilate (PZFX) to human serum albumin (HSA) or lysozyme (Lys) was investigated using spectrophotometric techniques. The intrinsic fluorescence of both HSA and Lys was strongly quenched by PZFX. This effect was rationalized in terms of a static quenching procedure. Negative values of ΔH 0 and ΔS 0 for the formation of PZFX–HSA or PZFX–Lys complex implied...
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