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Background
pH‐sensitive peptides are a relatively new strategy for conquering the poor endosomal release of cationic polymer‐mediated transfection. Modification of antimicrobial peptides by exchanging positively‐charged residues with negatively‐charged glutamic acid residues (Glu) greatly improves its lytic activity at the endosomal pH, which could improve cationic polymer‐mediated transfection....
Background
Poor endosomal release is a major barrier of polyplex‐mediated gene transfection. Antimicrobial peptides (AMPs) are commonly used to improve polyethylenimine (PEI)‐mediated gene transfection by increasing endosomal release. In the present study, we designed novel pH‐sensitive peptides that highly enhance transfection efficiency compared to their parent peptides.
Methods
Two analogues...
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