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A schematic representation of the tumor‐specific self‐degradable nanogels as potential carriers for systemic delivery of anticancer proteins described by Ran Mo and co‐workers in article number 1707371. The cocoon as representation of the nanogel can protect the fragile protein during circulation and release the protein by self‐degradation under tumor acidic conditions, like the metamorphosis of a...
Development of a safe and effective carrier for systemic protein delivery is highly desirable, which depends on management of the relationship among loading capacity, stability, delivery efficiency, and degradability. Here, a tumor‐specific self‐degradable nanogel composed of hyaluronidase (HAase)‐degradable hyaluronic acid (HA) matrices entrapping acid‐activatable HAase (aHAase) for systemic delivery...
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