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The present study determined the effect of maternal nicotine exposure during the early developmental period on AT 1 R and AT 2 R mRNA and protein abundance in the rat brain. Pregnant rats of day-4 gestation were implanted with osmotic minipumps that delivered nicotine at a dose rate of 6 mg/kg/day for 28 days. Neither fetal nor offspring brain weight was significantly altered by the...
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