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In order to probe the roles of PIP2 in the interactions between MIM I‐BAR and model membranes, we performed a series of 10 μs‐scale coarse‐grained molecular dynamics simulations. Our results indicate that PIP2 plays predominant roles in the membrane binding of MIM I‐BAR in a concentration‐dependent manner and via electrostatic interactions. Besides, we find that the occurrence of the membrane curvature...
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