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Possible neuroprotective actions of osteogenic protein-1 (OP-1) were evaluated in a rat model of cerebral hypoxia/ischemia. Intraperitoneal injection of 50 μg of OP-1 prior to bilateral carotid ligation and transient hypoxia in 12-day-old rats reduced cerebral infarct area from 44.8 ± 3.3% in vehicle-injected controls to 29 ± 4.9%. Treatment of 14-day-old rats with 20 μg of OP-1 1 h after hypoxia...
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