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The efficacy and tolerability of faldaprevir, a potent hepatitis C virus (HCV) NS3/4A protease inhibitor, plus peginterferon (PegIFN) and ribavirin (RBV) was assessed in a double-blind, placebo-controlled phase 3 study of treatment-naïve patients with HCV genotype-1 infection.Patients were randomly assigned (1:2:2) to PegIFN/RBV plus: placebo (arm 1, n=132) for 24weeks; faldaprevir (120mg, once daily)...
Differences in HCV-RNA clearance during therapy might explain the lower efficacy of peg-IFN/RBV in HIV/HCV-coinfection. There are limited data on HCV-RNA clearance and treatment outcomes in liver transplanted (LT) patients.To assess the rates of SVR and baseline predictors of failure after 48 weeks of weight-adjusted peg-IFN-α-2b/RBV in 120 patients with HCV genotype 1: 61 HCV-monoinfected, 40 HIV-coinfected...
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