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Abstract. A recombinant chimeric fusion protein, muIg-hu4.Fc, composed of the extracellular domain of mouse Ig (CD79b) and the CH2-CH3 domains of human IgG4.Fc (hu4.Fc), linked via an immunologically inert flexible peptide, was prepared. The fusion protein was evaluated for its ability to induce specific auto-reactive immune response against Ig and to modulate B cell activity in Balb/c mice. Upon...
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