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Personalized noninvasive imaging of subject-specific cardiac electrical activity can guide and improve preventive diagnosis and treatment of cardiac arrhythmia. Compared to body surface potential (BSP) recordings and electrophysiological information reconstructed on heart surfaces, volumetric myocardial transmembrane potential (TMP) dynamics is of greater clinical importance in exhibiting arrhythmic...
To noninvasively reconstruct transmembrane potential (TMP) dynamics throughout the 3D myocardium using body surface potential recordings, it is necessary to combine prior physiological models and patient's data with regard to their respective uncertainties. To fulfill model-data melding for this large-scale and high-dimensional system, data assimilation with proper computational reduction is needed...
Noninvasive imaging of cardiac electrophysiology has been an active area with increasing clinical significance. Instead of equivalent-source-based approaches, however, noninvasive 3D cardiac transmembrane potentials (TMP) mapping remains a formidable goal due to the remote and integrative nature of body surface potential recordings. We recognized the incorporation of a priori physiological knowledge...
We present a novel numerical scheme to accurately and efficiently simulate the spatiotemporal electrical propagation for three dimensional heart model. A meshfree particle representation of myocardial volume is first developed, upon which the electrical propagation can be obtained using the element-free Galerkin (EFG) method for the FitzHugh-Nagumo model. This method is based on a sufficient amount...
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