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Loss of response to TGF‐β is a central event in the genesis of colorectal cancer (CRC), a disease that, in the majority cases, is refractory to growth inhibition induced by this cytokine. However, inactivating mutations at receptors and transducers from the TGF‐β cascade occur only in approximately half of CRCs, suggesting the involvement of additional mechanisms altering the response to the cytokine...
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