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This work optimized the novel biotransformation process of podophyllotoxin to produce podophyllic acid by Pseudomonas aeruginosa CCTCC AB93066. Firstly, the biotransformation process was significantly affected by medium composition. 5g/l of yeast extract and 5g/l of peptone were favorable for podophyllic acid production (i.e. 25.3±3.7mg/l), while not beneficial for the cell growth of P. aeruginosa...
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