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Background
Mutations in human epidermal growth factor receptor 2 (HER2; also known as ERBB2) are found in approximately 2% of lung adenocarcinomas. The frequency and clinical course of brain metastases in this oncogenic subset are ill defined.
Methods
Baseline and subsequent development of brain metastases was evaluated in consecutive patients with HER2‐mutant (n = 98), epidermal growth factor...
BACKGROUND
In a phase 1 study of pulse/continuous‐dose erlotinib, no patient had disease progression in the central nervous system (CNS). This expansion cohort of the phase 1 study tested the same regimen in a cohort of individuals with epidermal growth factor receptor (EGFR)–mutant lung cancers with untreated brain metastases.
METHODS
Patients had not received EGFR tyrosine kinase inhibitors or...
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