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4′′-O-isovalerylspiramycins are the major components of bitespiramycin complex consisting of a group of 4′′-O-acylated spiramycins. The availability of isovaleryl group, usually in vivo derived from leucine, one of the branched-chain amino acids, affects the content of isovaleryispiramycin significantly. In this study, the effect of glucose on the activity of branched-chain α-keto acid dehydrogenase...
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