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CD4+CD127−CD25+FOXP3+ Regulatory T cells (Tregs) are shown to be enhanced in tolerant transplant patients and after ex vivo expansion to prolong graft survival in animal models without immunosuppression. Therefore, a number of centers have initiated clinical trials with expanded Tregs. The purpose of the present study was to further optimize the ex vivo expansion conditions and to characterize the...
Stable chimerism and tolerance can be achieved in HLA-disparate kidney recipients treated with donor hematopoietic stem cell (DHCS) transplantation supplemented with facilitating cells (FC) derived from mobilized peripheral blood (mPB) after living donor leukopheresis (Sci. Transl. Med. 2012; 4 (124): 124re28). The use of deceased donor (dd) vertebral body bone marrow (VBM), however, could extend...
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