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Low dose aspirin is used for prophylaxis of women at high risk to develop preeclampsia, but the mechanism for aspirin's beneficial effect is unknown. Cyclooxygenase (COX) enzyme activity is responsible for prostanoid production and is inhibited by aspirin. At low doses of aspirin, a differential inhibition of the vasoconstricting prostanoid thromboxane, while sparing the vasodilating prostanoid prostacyclin,...
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