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The restriction factor BST-2/tetherin contains two membrane anchors employed to retain some enveloped viruses, including HIV-1 tethered to the plasma membrane in the absence of virus-encoded antagonists. The 2.77 Å crystal structure of the BST-2/tetherin extracellular core presented here reveals a parallel 90 Å long disulfide-linked coiled-coil domain, while the complete extracellular domain forms...
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