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Asymmetric reduction of methyl o-chlorobenzoylformate (CBFM) using aldo-keto reductase YtbE is a potentially cost-effective and green technology in manufacturing methyl (R)-o-chloromandelate which is a key intermediate for synthesizing (S)-clopidogrel (a popular medicine for treating atherosclerosis). At the moment, large scale application of YtbE has been complicated by uncertain thermal and operational...
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