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Trigeminal stimulation of C-fibers increased c-fos expression within the trigeminal nucleus caudalis (NtV) and thalamic neuronal activity which both reflect the transmission of a nociceptive message. We examined the effects on both these phenomena of the selective NK 1 and NK 2 receptor antagonists, SR140333 and SR48968. SR140333 (0.3, 1 and 3 μg/kg intravenously [iv]) dose-dependently,...
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