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Matrix metalloproteinases (MMPs), a family of zinc-dependent proteases, have been recognized as a significant biomarker associated with tumor microenvironment. MMPs has been shown to enhance the expression of pro-angiogenic growth factors, such as VEGF and bFGF in colorectal cancer. A non-invasive imaging method that could enable MMPs assessment in vivo would enhance the understanding of the MMPs...
Sonodynamic therapy (SDT), based on synergistic effect of low intensity ultrasound and sonosensitizer, is a potential noninvasive approach for the treatment of cancers. It is shown that the subcellular distribution of sonosensitizer are varied with their properties and incubation time. However, the responses of cancer cells to localized SDT is still unclear. The aim of this study is to reveal bioeffect...
Colorectal cancer (CRC) remains the third most popular cancer in US. CRC biopsy usually shows substantially increased angiogenesis, which is promoted by a number of pro-angiogenic growth factors. Among all these factors, the expression of endoglin has been remarkably up-regulated on actively proliferating endothelial cells of neo-vasculature. Endoglin has been an independent clinical pathological...
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