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Integrating multiple datasets becomes essential for systematically understanding complex biological processes. Here, we presented a new method to identify and annotate the downstream pathways related to TNF-alpha (TNF) stimulus in vascular endothelial cells (VECs). It is found that the downstream pathways of TNF can both cause cell proliferation and cell death, which may provide an explanation for...
It has been shown that splicing is coupled with transcription and other upstream and downstream processes. However, the detailed mechanism is far from being well understood. In this paper, we investigated the coupling of splicing and transcription by studying alternative splicing (AS) of human genes possessing alternative promoters (AP). It was found that AS occurs more often in AP-containing genes...
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