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The quasimonoclonal mouse is useful to examine B cell selection during T-dependent antibody (Ab) responses because of its limited B cell populations mainly expressing the knockin 17.2.25 V H -encoded H chain (V H T) paired with the λ1 or λ2 L chain. It has been reported that both two V H T/λ1 and V H T/λ2 B cell populations responded to a T-dependent antigen conjugated...
The quasimonoclonal (QM) mouse provides a model to analyze B cell selection because major B cell antigen receptors (BCR) are composed of the knockin V H DJ H 17.2.25 (V H T) encoded H chain and the λ1 or λ2 L chain, thereby being specific for (4-hydoxy-3-nitrophenyl)acetyl (NP). We have reported that during a T-dependent antibody (Ab) response for a low-affinity NP analog p-nitrophenylacetyl...
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