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The efficacy of drugs targeting the CNS is influenced by their limited brain access, which can lead to complete pharmacoresistance. Recently a tissue‐specific and selective upregulation of the multidrug efflux transporter ABCB1 or P‐glycoprotein (P‐gp) in the spinal cord of both patients and the mutant SOD1‐G93A mouse model of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease...
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