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background: Critics of laparoscopic surgery cite an increased incidence of tumor recurrence at the trocar sites following laparoscopic cholecystectomy in patients incidentally found to have carcinoma of the gallbladder. The purpose of this review was to determine if laparoscopic cholecystectomy performed in patients with gallbladder cancer results in an increased incidence of abdominal wall recurrences...
Background. The c-src protooncogene encodes a protein tyrosine kinase, pp60 c-src , that is a mediator in many signal transduction pathways. One pathway in which pp60 c-src protein tyrosine kinase activity is implicated involves regulation of vascular endothelial growth factor (VEGF), an angiogenic factor important to neovascularization of growing...
Background. Vascular endothelial growth factor (VEGF) is a potent paracrine angiogenic factor implicated in human colon cancer angiogenesis. This study determined whether regulation of VEGF expression by human colon cancer cell lines affects endothelial cell proliferation in an in vitro model of angiogenesis.Methods. Human colon carcinoma cell lines were screened for VEGF mRNA expression. SW480 cells...
We determined whether the upregulation of several metastasis-related genes in human colon carcinoma (HCC) cells implanted into the cecal wall of nude mice precedes HCC invasion of the muscle layer and subserosa and, ultimately, distant metastasis. HCC KM12SM cells were implanted into the subcutis (ectopic) or cecal wall (orthotopic). At weekly intervals for up to 6 weeks, cecectomy and resection...
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