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(+)-Methamphetamine (METH) addiction is a chronic disease that interferes with fundamental brain-mediated behaviors and biological functions like eating. These studies present preclinical efficacy and safety profiles for a METH conjugate vaccine (IC KLH -SMO9) designed to treat METH abuse. IC KLH -SMO9 efficacy and safety were assessed over a 16-week period by monitoring general health...
These studies examined the in vivo pharmacokinetics and efficacy of five anti-methamphetamine monoclonal antibodies (mAbs, K D values from 11 to 250nM) in rats. While no substantive differences in mAb systemic clearance (t 1/2 =6.1–6.9 days) were found, in vivo function was significantly reduced within 1–3 days for four of the five mAbs. Only mAb4G9 was capable of prolonged efficacy,...
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