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Enrichment analysis methods, e.g., gene set enrichment analysis, represent one class of important bioinformatical resources for mining patterns in biomedical datasets. However, tools for inferring patterns and rules of a list of drugs are limited. In this study, we developed a web-based tool, DrugPattern, for drug set enrichment analysis. We first collected and curated 7019 drug sets, including indications,...
Pattern mining has been widely used to uncover interesting patterns from data. However, one of its main problems is that it produces too many patterns and many of them are redundant. To reduce the number of redundant patterns and retain overlapping ones, delta-closed pattern pruning was introduced, yet it can only prune subpatterns if they are covered by superpatterns. Such unduly superpatterns need...
The curse of dimensionality refers to the problem that one faces when analyzing datasets with thousands or hundreds of thousands of attributes. This problem is usually tackled by different feature selection methods which have been shown to effectively reduce computation time, improve prediction performance, and facilitate better understanding of datasets in various application areas. These methods...
A programmable DCO-based fast-locking clock generator is presented. With a resettable DCO, the clock generator achieves similar jitter performance as conventional MDLL and avoids the initial delay constraints by resetting the output clock every two reference cycles. Compared with the previous work, a shorter locking time is obtained. The proposed clock generator is simulated with generic 1.8 V-0.18...
For hyperspectral imagery, the term ldquospectral edgerdquo has not been clearly defined because of the complexity of the high dimensional properties in spectral space. In this paper, a new definition of the spectral edge is presented based on a data-driven mathematic approach Manifold Learning. It considers both the spectral features in spectral space and the discontinuity of image function in image...
A quantitative structure-activity relationship study based on stepwise regression analysis for the anti-ulcerogenic activities (percentage inhibition of ulceration) of 12 sesquiterpene lactones was performed and the linear regression model between anti-ulcerogenic activities and their molecular descriptors was established (R = 0.9825). Anti-ulcerogenic activity has significant negative correlation...
Several metrics have been proposed in literature to assess the quality of 2D images, but the metrics devoted to quality assessment of stereoscopic images are very scarce. Therefore, in this paper, an objective assessment method is proposed to predict the quality level of stereoscopic images. This method assesses stereo images from the perspective of image quality and stereo sense. Experiments demonstrate...
Lee et al proposed two methods to speed up the computation of scalar multiplication of elliptic curve defined over GF(2mn) with a medium size of m in the range 10 les m les 20. In these methods, Frobenius map is utilized to expand the integer k and each coefficient of the expansion is represented as a binary string. In this paper, with the application of joint sparse form (JSF) to the coefficients,...
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