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ObjectiveKashin‐Beck disease (KBD) is a chronic osteochondropathy, the pathogenesis of which remains elusive. The aim of this study was to identify susceptibility genes for KBD by conducting a 2‐stage genome‐wide association study (GWAS).
MethodsNinety patients with grade II or grade III KBD with extreme KBD phenotypes and 1,627 healthy control subjects were enrolled in the initial GWAS. Affymetrix...
ObjectiveTo investigate the differences in gene expression profiles of adult articular cartilage from patients with Kashin‐Beck disease (KBD) versus those with primary knee osteoarthritis (OA).
MethodsThe messenger RNA expression profiles of articular cartilage from patients with KBD, diagnosed according to the clinical criteria for KBD in China, were compared with those of cartilage from patients...
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