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Pancreatic ductal adenocarcinoma (PDAC) is expected to become the second cause of cancer-related death in 2030. PDAC is the poorest prognostic tumor of the digestive tract, with 80% of patients having advanced disease at diagnosis and 5-year survival rate not exceeding 7%.Until 2010, gemcitabine was the only validated therapy for advanced PDAC with a modest improvement in median overall survival as...
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