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Intensive insulin therapy (IIT) and tight glycaemic control (TGC), particularly in intensive care unit (ICU), are the subjects of increasing and controversial debate in recent years. Model-based TGC has shown potential in delivering safe and tight glycaemic management, all the while limiting hypoglycaemia. A comprehensive, more physiologically relevant Intensive Control Insulin-Nutrition-Glucose (ICING)...
A comprehensive, more physiologically relevant Intensive Control Insulin-Nutrition-Glucose (ICING) Model is presented and validated using data from critically ill patients. Glucose utilisation and its endogenous production in particular, are more distinctly expressed. A more robust glucose absorption model through ingestion is also added. Finally, this model also includes explicit pathways of insulin...
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