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The biologically active form of vitamin D3, 1, 25‐dihydroxyvitamin D3 (calcitriol), is a potent modulator of the immune response. We have shown previously that calcitriol modulates the immunoglobulin response in vitro and in vivo in mice and humans. To analyse the underlying molecular mechanisms we studied whether calcitriol‐primed B cells modulate T cell activation and function. Human B cells were...
To cite this article: Hartmann B, Heine G, Babina M, Steinmeyer A, Zügel U, Radbruch A, Worm M. Targeting the vitamin D receptor inhibits the B cell‐dependent allergic immune response. Allergy 2011; 66: 540–548.
AbstractBackground: 1α,25‐dihydroxyvitamin D3 (calcitriol), the biologically active form of vitamin D, is an immunomodulatory hormone, e.g. it inhibits IgE synthesis in B cells. As its clinical...
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