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Background
Degeneration of the cortically‐projecting cholinergic basal forebrain (cBF) is a well‐established pathologic correlate of cognitive decline in Parkinson's disease (PD). In Alzheimer's disease (AD) the effect of cBF degeneration on cognitive decline was found to be mediated by parallel atrophy of denervated cortical areas.
Objectives
To examine whether the association between cBF degeneration...
Background
Peripheral inflammatory immune responses are suggested to play a major role in dopaminergic degeneration in Parkinson's disease (PD). The neutrophil‐to‐lymphocyte ratio (NLR) is a well‐established biomarker of systemic inflammation in PD. Degeneration of the nigrostriatal dopaminergic system can be assessed in vivo using [123I]FP‐CIT single photon emission computed tomography imaging of...