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Activated mucosal T lymphocytes correlate withthe intestinal inflammation of inflammatory boweldisease. Activated T cells elaborate interferon-γ(IFN-γ) and express high-affinity interleukin-2(IL-2) receptors. The IL-2/diphtheria toxin fusionprotein (DAB389IL-2) has been shown tospecifically kill high affinity IL-2 receptor-bearingcells. We tested whether DAB389IL-2 couldspecifically target activated...
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