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Stem Cell Gym
In article number 2302829, Yu Wang, Lisha Zheng, Yubo Fan, and co‐workers develop a micropatterned based stem cell gym to train dental pulp stem cells for stemness maintenance. The micropattern based gym with 1024 μm2 and aspect ratios of 1:2 and 1:4 effectively enhances the stemness and rescues the pluripotency of stem cells during long‐term expansion. The stem cell gym‐induced mechanical...
Dental pulp stem cells (DPSCs) which are derived from the neural crest are promising tools in stem cell therapy in the clinic. However, they tend to lose their multi‐lineage potency spontaneously during long‐term expansion in vitro. A micropattern‐based system is developed to train DPSCs with 1024 µm2 and aspect ratios of 1:2 and 1:4, which enhances their stemness and differentiation potential. This...
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