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Fms‐like tyrosine kinase 3 (FLT3) is widely expressed and often mutated in acute myeloid leukemia (AML), which makes it an important target for the treatment of AML. The structure‐based synthesis and biological evaluation of 5,6‐dihydrobenzo[h]quinazoline derivatives as FLT3 inhibitors have been studied in this paper. III‐1a, III‐1c, III‐2a, III‐2c, and III‐4a displayed comparable inhibitory potency...