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Isocorynoxeine (ICN) is one of the major bioactive tetracyclic oxindole alkaloids found in Uncaria rhynchophylla (Miq.) Jacks. that is widely used for the treatment of hypertension, vascular dementia, and stroke. The present study was undertaken to assess the plasma pharmacokinetic characteristics of major ICN metabolites, and the role of simulated gastric and intestinal fluid (SGF and SIF), human...
To investigate hepatotoxic constituents, a new cycloartane-type triterpenoid ketone together with four known components was isolated from rhizomes of Curculigo orchioides. The structures of five compounds were elucidated on the basis of spectroscopic methods, including 1D and 2D NMR, and single-crystal X-ray diffraction analysis. Their hepatotoxicity effects in human hepatic cell line HL-7702 were...
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