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Hydrogen sulfide (H2S) is a kind of gaseous signalling molecule that plays pivotal role in various biological processes. So far, it is still a challenge to develop convenient and reliable methods for H2S detection in lysosomes. Herein, we developed a novel ratiometric two-photon fluorescent probe LR-H2S for imaging H2S in lysosomes. Upon the addition of H2S (using Na2S as a donor) to LR-H2S in buffer...
A new water-soluble two-photon probe CuL 2 for pyrophosphate anion (PPi) is designed and synthesized, and shows turn-on fluorescence with high sensitivity and selectivity. The probe CuL 2 can selectively detect small amount of PPi particularly in the presence of a large excess of PO 43− and ATP. The association constant of CuL 2 and PPi is about 10 5.2 ...
Lysosomes are vital organelles in physiological processes, as they receive and degrade macromolecules from the secretory and endocytic procedures. Evidences have shown that lysosomes were related to oncogenic activation and cancer progression, so lysosomes targeting and imaging probes make them convenient to be observed. In this study, a lysosome specific probe W-7 was designed and synthesized via...
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