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O-superfamily conotoxins include several families that have diverse pharmacological activity on Na + , K + or Ca 2+ channels. These superfamily toxins have been mainly found in fish-hunting and mollusk-hunting Conus species. Here, we reported two novel O-superfamily conotoxins, vx6a and vx6b, purified from a worm-hunting cone snail, Conus vexillum. Though their cysteine framework...
μ-Conotoxin SIIIA, a novel blocker of tetrodotoxin-resistant (TTX-R) voltage-gated sodium channels (VGSCs) has been identified from the fish-hunting cone snail, Conus striatus. The deduced sequence consists of a 20-residue signal peptide, a 31-residue pro-peptide, and a 20-residue mature toxin with its N-terminal Gln cyclized and C-terminus amidated. μ-SIIIA shares the common cysteine arrangement...
The full-length cDNAs of two A-superfamily conotoxins, κA-SIVA and α-SII, were respectively cloned and sequenced from Conus striatus using 3' RACE and 5' RACE. The cDNA of κA-SIVA encodes a precursor of 68 residues, including a signal peptide of 21 residues, a pro-peptide of 17 residues, and a mature peptide of 30 residues with an additional residue Gly which is prerequisite for the amidation of the...
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