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A 29 amino-acid peptide derived from the rabies virus glycoprotein (RVG29) was exploited as a ligand for efficient brain-targeting gene delivery. RVG29 was modified on polyamidoamine dendrimers (PAMAM) through bifunctional PEG, then complexed with DNA, yielding PAMAM–PEG–RVG29/DNA nanoparticles (NPs). The NPs were observed to be uptaken by brain capillary endothelial cells (BCECs) through a clathrin...
The software industry in China continues to expand at a rapid rate, both in terms of research and development as well as the ever-increasing need for outsourcing. Even with these great demands China is able to produce a vast, highly-qualified pool of computer science graduates. The education system in China has clearly adjusted to the trends of the industry while maintaining the traditional, rigorous...
Behavioral analysis refers to the technique of deciding whether an application is malicious or not, according to what it does. With behavioral analysis research on executables evolving, it is difficult to classify malicious applications and some legal applications called dasiagray applicationpsila, which are classified as malicious sample by dasiaweakpsila learners. In theory, boosting can be used...
A domain-analysis based process was developed to facilitate software reuse. This process starts with analyzing domain common features/differences systematically based on software architectural considerations. The end result of domain-analysis is a domain model with a collection of well-defined and well-developed packages/components ready for reuse. The advantages of domain-analysis were demonstrated...
Chemoreceptor cells have temporally dynamic physiological properties that serve as filters for fluctuating odor patterns. A computational model, based on an electrical circuit, of a peripheral chemoreceptor cell was developed based on two time constants (τ 1 and τ 2 ) that model sensory adaptation and recovery from adaptation. With τ 1 set to 0.1 s and τ 2 to 3.8 s,...
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