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Type 5 17β-HSD, one of the seven types of 17β-hydroxysteroid dehydrogenase (17β-HSD) so far characterized in humans, catalyzes the transformation of 4-androstenedione (4-dione) into testosterone (T). This reaction is also catalyzed by type 3 17β-HSD which is responsible for pseudohermaphroditism in deficient man but is asymptomatic in deficient women. Since type 3 17β-HSD is not found in the ovary,...
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